| 1 | ABBV | AbbVie Inc | $449B | 118.9 | 2.8% | 12 |
| 2 | AMGN | Amgen Inc | $201B | 25.9 | 2.7% | 12 |
| 3 | GILD | Gilead Sciences Inc | $169B | 18.5 | 2.4% | 12 |
| 4 | VRTX | Vertex Pharmaceuticals Inc | $123B | 28.3 | — | 12 |
| 5 | REGN | Regeneron Pharmaceuticals Inc | $71.2B | 16.2 | 0.5% | 12 |
| 6 | ARGX | argenx NV ADR | $53.4B | 38.3 | — | 12 |
| 7 | HLN | Haleon plc | $44.5B | 20.6 | 2.0% | 7 |
| 8 | NTRA | Natera Inc | $38.6B | — | — | 12 |
| 9 | RVMD | Revolution Medicines Inc | $38.1B | — | — | 9 |
| 10 | ALNY | Alnylam Pharmaceuticals Inc | $37.8B | 69.9 | — | 12 |
| 11 | ONC | BeiGene, Ltd. | $32.9B | 70.4 | — | 12 |
| 12 | BIIB | Biogen Inc | $30.8B | 22.4 | — | 12 |
| 13 | MRNA | Moderna Inc | $25.1B | — | — | 12 |
| 14 | ROIV | Roivant Sciences Ltd | $24.4B | — | — | 8 |
| 15 | INCY | Incyte Corporation | $23.3B | 16.3 | — | 12 |
| 16 | INSM | Insmed Inc | $23.3B | — | — | 12 |
| 17 | BNTX | BioNTech SE | $23.2B | — | — | 9 |
| 18 | UTHR | United Therapeutics Corporation | $22.5B | 19.5 | — | 12 |
| 19 | GMAB | Genmab AS | $17.8B | 22.1 | — | 12 |
| 20 | NBIX | Neurocrine Biosciences Inc | $17.2B | 26.5 | — | 12 |
| 21 | ASND | Ascendis Pharma AS | $17B | 30.1 | — | 12 |
| 22 | BBIO | BridgeBio Pharma Inc | $15.7B | — | — | 9 |
| 23 | EXEL | Exelixis Inc | $14B | 18.4 | — | 12 |
| 24 | MDGL | Madrigal Pharmaceuticals Inc | $12.6B | — | — | 12 |
| 25 | ABVX | Abivax SA American Depositary Shares | $11.9B | — | — | 12 |
| 26 | BMRN | Biomarin Pharmaceutical Inc | $11.6B | 42.3 | — | 12 |
| 27 | CYTK | Cytokinetics Inc | $11B | — | — | 12 |
| 28 | SMMT | Summit Therapeutics PLC | $10.7B | — | — | 12 |
| 29 | KRYS | Krystal Biotech Inc | $10.5B | 47.4 | — | 10 |
| 30 | APGE | Apogee Therapeutics, Inc. Common Stock | $10.1B | — | — | 4 |
| 31 | ARWR | Arrowhead Pharmaceuticals Inc | $10.1B | — | — | 12 |
| 32 | KYMR | Kymera Therapeutics Inc | $9.82B | — | — | 8 |
| 33 | NUVL | Nuvalent Inc | $9.8B | — | — | 7 |
| 34 | IONS | Ionis Pharmaceuticals Inc | $9.63B | — | — | 12 |
| 35 | PRAX | Praxis Precision Medicines Inc | $9.06B | — | — | 8 |
| 36 | HALO | Halozyme Therapeutics Inc | $9.04B | 26.7 | — | 12 |
| 37 | CRNX | Crinetics Pharmaceuticals Inc | $8.85B | — | — | 10 |
| 38 | TGTX | TG Therapeutics Inc | $8.74B | 20.0 | — | 12 |
| 39 | ALKS | Alkermes Plc | $8.66B | 57.7 | — | 12 |
| 40 | IBRX | Immunitybio Inc | $8.61B | — | — | 12 |
| 41 | SYRE | Spyre Therapeutics Inc. | $8.58B | — | — | 12 |
| 42 | PTGX | Protagonist Therapeutics Inc | $8.45B | — | — | 12 |
| 43 | PCVX | Vaxcyte Inc | $8.41B | — | — | 9 |
| 44 | IMVT | Immunovant Inc | $8.15B | — | — | 10 |
| 45 | MIRM | Mirum Pharmaceuticals Inc | $7.45B | — | — | 8 |
| 46 | RYTM | Rhythm Pharmaceuticals Inc | $7.44B | — | — | 12 |
| 47 | PTCT | PTC Therapeutics Inc | $6.99B | — | — | 12 |
| 48 | SRRK | Scholar Rock Holding Corp | $6.8B | — | — | 10 |
| 49 | XENE | Xenon Pharmaceuticals Inc | $6.66B | — | — | 12 |
| 50 | COGT | Cogent Biosciences Inc | $6.64B | — | — | 11 |
| 51 | CGON | CG Oncology, Inc. Common stock | $6.64B | — | — | 5 |
| 52 | LGND | Ligand Pharmaceuticals Incorporated | $6.34B | 41.2 | — | 12 |
| 53 | BLTE | Belite Bio Inc ADR | $5.99B | — | — | 6 |
| 54 | ERAS | Erasca Inc | $5.76B | — | — | 7 |
| 55 | TWST | Twist Bioscience Corp | $5.64B | — | — | 10 |
| 56 | CRSP | Crispr Therapeutics AG | $5.55B | — | — | 12 |
| 57 | CELC | Celcuity LLC | $5.54B | — | — | 11 |
| 58 | DNTH | Dianthus Therapeutics Inc. | $5.32B | — | — | 10 |
| 59 | TVTX | Travere Therapeutics Inc | $5.26B | — | — | 12 |
| 60 | APLS | Apellis Pharmaceuticals Inc | $5.25B | 38.3 | — | 12 |
| 61 | LEGN | Legend Biotech Corp | $5.24B | — | — | 9 |
| 62 | ORKA | Oruka Therapeutics, Inc. | $5.23B | — | — | 12 |
| 63 | TNGX | Tango Therapeutics Inc | $5.06B | — | — | 7 |
| 64 | GRFS | Grifols SA ADR | $4.95B | 10.5 | 3.9% | 12 |
| 65 | EWTX | Edgewise Therapeutics Inc | $4.89B | — | — | 7 |
| 66 | KNSA | Kiniksa Pharmaceuticals Ltd | $4.88B | 69.7 | — | 10 |
| 67 | INDV | Indivior PLC Ordinary Shares | $4.79B | 21.2 | — | 10 |
| 68 | VCYT | Veracyte Inc | $4.55B | 52.8 | — | 12 |
| 69 | VKTX | Viking Therapeutics Inc | $4.51B | — | — | 12 |
| 70 | ACAD | ACADIA Pharmaceuticals Inc | $4.49B | 11.9 | — | 12 |
| 71 | RLAY | Relay Therapeutics Inc | $4.36B | — | — | 8 |
| 72 | NAMS | NewAmsterdam Pharma Company N.V. Ordinary Shares | $4.2B | — | — | 6 |
| 73 | DNLI | Denali Therapeutics Inc | $4.08B | — | — | 11 |
| 74 | GPCR | Structure Therapeutics Inc. American Depositary Shares | $3.92B | — | — | 6 |
| 75 | DYN | Dyne Therapeutics Inc | $3.87B | — | — | 12 |
| 76 | CPRX | Catalyst Pharmaceuticals Inc | $3.85B | 18.2 | — | 12 |
| 77 | RCUS | Arcus Biosciences Inc | $3.64B | — | — | 10 |
| 78 | ALMS | Alumis Inc | $3.61B | — | — | 4 |
| 79 | IDYA | Ideaya Biosciences Inc | $3.56B | — | — | 9 |
| 80 | ARQT | Arcutis Biotherapeutics Inc | $3.47B | — | — | 9 |
| 81 | BEAM | Beam Therapeutics Inc | $3.36B | — | — | 9 |
| 82 | RARE | Ultragenyx | $3.33B | — | — | 12 |
| 83 | GRAL | GRAIL, LLC | $3.09B | — | — | 8 |
| 84 | CLDX | Celldex Therapeutics Inc | $3.07B | — | — | 12 |
| 85 | VERA | Vera Therapeutics Inc | $3.01B | — | — | 7 |
| 86 | QURE | Uniqure NV | $2.93B | — | — | 12 |
| 87 | MBX | MBX Biosciences, Inc. Common Stock | $2.91B | — | — | 4 |
| 88 | IRON | Disc Medicine Inc. | $2.9B | — | — | 6 |
| 89 | BCRX | BioCryst Pharmaceuticals Inc | $2.66B | — | — | 12 |
| 90 | IMNM | Immunome Inc | $2.64B | — | — | 8 |
| 91 | KOD | Kodiak Sciences Inc | $2.59B | — | — | 10 |
| 92 | SLS | Sellas Life Sciences Group Inc | $2.51B | — | — | 12 |
| 93 | RGC | Regencell Bioscience Holdings Ltd | $2.5B | — | — | 12 |
| 94 | AGIO | Agios Pharm | $2.45B | — | — | 12 |
| 95 | PHVS | Pharvaris BV | $2.45B | — | — | 8 |
| 96 | MLYS | Mineralys Therapeutics, Inc. Common Stock | $2.45B | — | — | 6 |
| 97 | VCEL | Vericel Corp Ord | $2.4B | 109.3 | — | 12 |
| 98 | NRIX | Nurix Therapeutics Inc | $2.39B | — | — | 8 |
| 99 | BHVN | Biohaven Ltd. | $2.34B | — | — | 8 |
| 100 | ZLAB | Zai Lab Ltd | $2.31B | — | — | 11 |
| 101 | VRDN | Viridian Therapeutics Inc | $2.18B | — | — | 12 |
| 102 | ADMA | ADMA Biologics Inc | $2.1B | 13.4 | — | 12 |
| 103 | SNDX | Syndax Pharmaceuticals Inc | $2.09B | — | — | 12 |
| 104 | PVLA | Palvella Therapeutics, Inc | $2.08B | — | — | 12 |
| 105 | NBTX | Nanobiotix | $2.03B | — | — | 12 |
| 106 | AUPH | Aurinia Pharmaceuticals Inc | $2.03B | 7.3 | — | 12 |
| 107 | NUVB | Nuvation Bio Inc | $2.02B | — | — | 8 |
| 108 | SRPT | Sarepta Therapeutics Inc | $2B | 54.1 | — | 12 |
| 109 | MESO | Mesoblast Ltd | $2B | — | — | 12 |
| 110 | SION | Sionna Therapeutics, Inc. Common Stock | $1.99B | — | — | 4 |
| 111 | NTLA | Intellia Therapeutics Inc | $1.99B | — | — | 12 |
| 112 | ANAB | AnaptysBio Inc | $1.97B | — | — | 12 |
| 113 | STOK | Stoke Therapeutics Inc | $1.95B | — | — | 9 |
| 114 | TYRA | Tyra Biosciences Inc | $1.95B | — | — | 7 |
| 115 | GLUE | Monte Rosa Therapeutics Inc | $1.95B | — | — | 7 |
| 116 | ZYME | Zymeworks Inc. Common Stock | $1.9B | — | — | 12 |
| 117 | ATAI | ATAI Life Sciences BV | $1.9B | — | — | 7 |
| 118 | BCAX | Bicara Therapeutics Inc. Common Stock | $1.9B | — | — | 4 |
| 119 | PGEN | Precigen Inc | $1.9B | — | — | 12 |
| 120 | RXRX | Recursion Pharmaceuticals Inc | $1.89B | — | — | 7 |
| 121 | IOVA | Iovance Biotherapeutics Inc | $1.89B | — | — | 12 |
| 122 | URGN | UroGen Pharma Ltd | $1.88B | — | — | 12 |
| 123 | ABCL | Abcellera Biologics Inc | $1.82B | — | — | 8 |
| 124 | TSHA | Taysha Gene Therapies Inc | $1.82B | — | — | 7 |
| 125 | GHRS | GH Research PLC | $1.82B | — | — | 7 |
| 126 | ZBIO | Zenas BioPharma, Inc. Common Stock | $1.81B | — | — | 4 |
| 127 | MPLT | MapLight Therapeutics, Inc. Common Stock | $1.8B | — | — | 4 |
| 128 | ABSI | Absci Corp | $1.8B | — | — | 7 |
| 129 | AAPG | Ascentage Pharma Group International | $1.78B | — | — | 10 |
| 130 | VIR | Vir Biotechnology Inc | $1.68B | — | — | 9 |
| 131 | MLTX | MoonLake Immunotherapeutics | $1.65B | — | — | 6 |
| 132 | IMCR | Immunocore Holdings Ltd | $1.63B | — | — | 12 |
| 133 | AVBP | ArriVent BioPharma, Inc. Common Stock | $1.57B | — | — | 5 |
| 134 | NVAX | Novavax Inc | $1.53B | — | — | 12 |
| 135 | CDNA | CareDx Inc | $1.47B | — | — | 12 |
| 136 | INBX | Inhibrx Biosciences, Inc. | $1.36B | — | — | 10 |
| 137 | IMTX | Immatics NV | $1.32B | — | — | 8 |
| 138 | CRVS | Corvus Pharmaceuticals Inc | $1.32B | — | — | 12 |
| 139 | ARDX | Ardelyx Inc | $1.3B | — | — | 12 |
| 140 | JBIO | Jade Biosciences, Inc. | $1.28B | — | — | 6 |
| 141 | MNKD | MannKind Corp | $1.26B | — | — | 12 |
| 142 | CAPR | Capricor Therapeutics Inc | $1.25B | — | — | 12 |
| 143 | MGTX | MeiraGTx Holdings PLC | $1.24B | — | — | 10 |
| 144 | SVRA | Savara Inc | $1.24B | — | — | 12 |
| 145 | XNCR | Xencor Inc | $1.18B | — | — | 12 |
| 146 | DRTS | Alpha Tau Medical Ltd | $1.15B | — | — | 7 |
| 147 | ORIC | Oric Pharmaceuticals Inc | $1.12B | — | — | 9 |
| 148 | ALVO | Alvotech | $1.12B | — | — | 7 |
| 149 | CGEM | Cullinan Oncology LLC | $1.11B | — | — | 12 |
| 150 | SANA | Sana Biotechnology Inc | $1.07B | — | — | 8 |
| 151 | OLMA | Olema Pharmaceuticals Inc | $1.04B | — | — | 8 |
| 152 | VOR | Vor Biopharma Inc | $1.04B | — | — | 8 |
| 153 | SLDB | Solid Biosciences LLC | $1.03B | — | — | 11 |
| 154 | OPK | Opko Health Inc | $1.02B | — | — | 12 |
| 155 | KURA | Kura Oncology Inc | $1.02B | — | — | 12 |
| 156 | IVA | Inventiva Sa | $1.02B | — | — | 12 |
| 157 | AVTX | Avalo Therapeutics Inc | $1.01B | — | — | 12 |
| 158 | BTX | BlackRock Technology and Private Equity Term Trust | $1.01B | 23.4 | 0.0% | 12 |
| 159 | JANX | Janux Therapeutics Inc | $1B | — | — | 7 |
| 160 | GRCL | Gracell Biotechnologies Inc. | $990M | — | — | 6 |
| 161 | EVO | Evotec SE ADR | $989M | — | — | 12 |
| 162 | LXRX | Lexicon Pharmaceuticals Inc | $986M | — | — | 12 |
| 163 | PHAR | Pharming Group NV | $979M | 72.9 | — | 12 |
| 164 | DBVT | DBV Technologies | $976M | — | — | 12 |
| 165 | GERN | Geron Corporation | $962M | — | — | 12 |
| 166 | ANNX | Annexon Inc | $950M | — | — | 9 |
| 167 | DSGN | Design Therapeutics Inc | $949M | — | — | 7 |
| 168 | ABUS | Arbutus Biopharma Corp | $948M | 5.8 | — | 12 |
| 169 | REPL | Replimune Group Inc | $923M | — | — | 10 |
| 170 | FBRX | Forte Biosciences Inc | $899M | — | — | 11 |
| 171 | NGNE | Neurogene Inc | $855M | — | — | 12 |
| 172 | OCS | Oculis Holding AG Ordinary shares | $823M | — | — | 6 |
| 173 | ESPR | Esperion Therapeutics Inc | $819M | — | — | 12 |
| 174 | CTMX | CytomX Therapeutics Inc | $819M | — | — | 12 |
| 175 | ZVRA | Zevra Therapeutics Inc. | $793M | 7.0 | — | 12 |
| 176 | IMMX | Immix Biopharma Inc | $791M | — | — | 7 |
| 177 | SPRY | ARS Pharmaceuticals, Inc | $788M | — | — | 8 |
| 178 | RIGL | Rigel Pharmaceuticals Inc | $787M | 2.2 | — | 12 |
| 179 | XOMA | XOMA Royalty Corporation | $782M | 28.2 | — | 12 |
| 180 | CLYM | Climb Bio Inc | $771M | — | — | 7 |
| 181 | DRUG | Bright Minds Biosciences Inc | $764M | — | — | 7 |
| 182 | IRWD | Ironwood Pharmaceuticals Inc | $736M | 7.2 | — | 12 |
| 183 | GYRE | Gyre Therapeutics Inc. | $727M | — | — | 12 |
| 184 | RGNX | Regenxbio Inc | $721M | — | — | 12 |
| 185 | CSTL | Castle Biosciences Inc | $719M | — | — | 9 |
| 186 | MNPR | Monopar Therapeutics Inc | $714M | — | — | 11 |
| 187 | AURA | Aura Biosciences Inc | $708M | — | — | 7 |
| 188 | CADL | Candel Therapeutics Inc | $695M | — | — | 7 |
| 189 | ALLO | Allogene Therapeutics Inc | $690M | — | — | 9 |
| 190 | PRME | Prime Medicine, Inc. Common Stock | $683M | — | — | 7 |
| 191 | BBOT | BridgeBio Oncology Therapeutics, Inc. | $666M | — | — | 5 |
| 192 | TECX | Tectonic Therapeutic, Inc. | $654M | — | — | 10 |
| 193 | FDMT | 4D Molecular Therapeutics Inc | $644M | — | — | 9 |
| 194 | SVA | Sinovac Biotech Ltd | $642M | 6.7 | — | 12 |
| 195 | ANL | Adlai Nortye Ltd. American Depositary Shares | $642M | — | — | 7 |
| 196 | STTK | Shattuck Labs Inc | $634M | — | — | 8 |
| 197 | ACHV | Achieve Life Sciences Inc | $627M | — | — | 12 |
| 198 | MDXG | MiMedx Group Inc | $612M | 20.6 | — | 12 |
| 199 | DNA | Ginkgo Bioworks Holdings | $594M | — | — | 7 |
| 200 | ALT | Altimmune Inc | $593M | — | — | 12 |
| 201 | NVCT | Nuvectis Pharma Inc | $578M | — | — | 6 |
| 202 | MYGN | Myriad Genetics Inc | $551M | — | — | 12 |
| 203 | ASMB | Assembly Biosciences Inc | $543M | 342.5 | — | 12 |
| 204 | PROK | ProKidney Corp. | $526M | — | — | 7 |
| 205 | KYTX | Kyverna Therapeutics, Inc. Common Stock | $516M | — | — | 5 |
| 206 | VALN | Valneva SE ADR | $516M | — | — | 12 |
| 207 | EDIT | Editas Medicine Inc | $500M | — | — | 12 |
| 208 | OCGN | Ocugen Inc | $498M | — | — | 12 |
| 209 | ZURA | Zura Bio Limited Class A Ordinary Shares | $493M | — | — | 5 |
| 210 | STRO | Sutro Biopharma | $493M | — | — | 10 |
| 211 | VSTM | Verastem Inc | $486M | — | — | 12 |
| 212 | CABA | Cabaletta Bio Inc | $485M | — | — | 9 |
| 213 | PRTA | Prothena Corporation plc | $484M | — | — | 12 |
| 214 | CBIO | Crescent Biopharma, Inc. | $478M | — | — | 12 |
| 215 | OVID | Ovid Therapeutics Inc | $470M | — | — | 12 |
| 216 | TENX | Tenax Therapeutics Inc | $466M | — | — | 12 |
| 217 | BNTC | Benitec Biopharma Ltd ADR | $461M | — | — | 12 |
| 218 | RZLT | Rezolute Inc | $457M | — | — | 12 |
| 219 | ARTV | Artiva Biotherapeutics, Inc. Common Stock | $457M | — | — | 6 |
| 220 | SGMT | Sagimet Biosciences Inc. Series A Common Stock | $455M | — | — | 7 |
| 221 | CCCC | C4 Therapeutics Inc | $449M | — | — | 8 |
| 222 | LRMR | Larimar Therapeutics Inc | $445M | — | — | 12 |
| 223 | EPRX | Eupraxia Pharmaceuticals Inc. Common Stock | $436M | — | — | 9 |
| 224 | SLN | Silence Therapeutics PLC | $429M | — | — | 12 |
| 225 | AUTL | Autolus Therapeutics Ltd | $428M | — | — | 12 |
| 226 | RCKT | Rocket Pharmaceuticals Inc | $427M | — | — | 12 |
| 227 | PRTC | PureTech Health PLC | $424M | — | — | 12 |
| 228 | CMPX | Compass Therapeutics Inc. | $420M | — | — | 8 |
| 229 | XFOR | X4 Pharmaceuticals Inc | $416M | — | — | 11 |
| 230 | EBS | Emergent Biosolutions Inc | $415M | — | — | 12 |
| 231 | DMAC | DiaMedica Therapeutics Inc | $413M | — | — | 12 |
| 232 | NNNN | Anbio Biotechnology Class A Ordinary Shares | $412M | 72.2 | — | 5 |
| 233 | KMDA | Kamada | $411M | 20.3 | 3.5% | 12 |
| 234 | UPB | Upstream Bio, Inc. | $410M | — | — | 4 |
| 235 | PBYI | Puma Biotechnology Inc | $407M | 16.7 | — | 12 |
| 236 | IPSC | Century Therapeutics Inc | $406M | — | — | 9 |
| 237 | ENTA | Enanta Pharmaceuticals Inc | $398M | — | — | 12 |
| 238 | ABEO | Abeona Therapeutics Inc | $398M | 7.3 | — | 12 |
| 239 | PRLD | Prelude Therapeutics Inc | $383M | — | — | 8 |
| 240 | LXEO | Lexeo Therapeutics, Inc. Common Stock | $378M | — | — | 6 |
| 241 | AKBA | Akebia Ther | $376M | — | — | 12 |
| 242 | VNDA | Vanda Pharmaceuticals Inc | $375M | — | — | 12 |
| 243 | FENC | Fennec Pharmaceuticals Inc | $364M | — | — | 12 |
| 244 | FATE | Fate Therapeutics Inc | $361M | — | — | 12 |
| 245 | INDP | Indaptus Therapeutics Inc | $350M | — | — | 12 |
| 246 | LYEL | Lyell Immunopharma Inc | $350M | — | — | 7 |
| 247 | FHTX | Foghorn Therapeutics Inc | $349M | — | — | 8 |
| 248 | ZNTL | Zentalis Pharmaceuticals Llc | $347M | — | — | 8 |
| 249 | PALI | Palisade Bio Inc | $341M | 16.3 | — | 12 |
| 250 | OABI | OmniAb Inc. | $332M | — | — | 7 |
| 251 | IMRX | Immuneering Corp | $331M | — | — | 7 |
| 252 | AMRN | Amarin Corporation PLC | $312M | — | — | 12 |
| 253 | ORGO | Organogenesis Holdings Inc | $309M | — | — | 12 |
| 254 | BCYC | Bicycle Therapeutics Ltd | $308M | — | — | 10 |
| 255 | IFRX | InflaRx N.V. | $302M | — | — | 11 |
| 256 | CLLS | Cellectis SA | $301M | — | — | 12 |
| 257 | ELDN | Eledon Pharmaceuticals Inc | $297M | — | — | 12 |
| 258 | SABS | SAB Biotherapeutics Inc | $292M | — | — | 7 |
| 259 | LCTX | Lineage Cell Therapeutics Inc | $292M | — | — | 12 |
| 260 | GLSI | Greenwich Lifesciences Inc | $291M | — | — | 9 |
| 261 | TKNO | Alpha Teknova Inc | $287M | — | — | 7 |
| 262 | ALXO | Alx Oncology Holdings | $286M | — | — | 8 |
| 263 | RNAC | Cartesian Therapeutics Inc. | $278M | — | — | 12 |
| 264 | MGNX | MacroGenics Inc | $275M | — | — | 12 |
| 265 | IKT | Inhibikase Therapeutics Inc | $269M | — | — | 10 |
| 266 | SRZN | Surrozen Inc | $269M | — | — | 7 |
| 267 | TRDA | Entrada Therapeutics Inc | $269M | — | — | 7 |
| 268 | GALT | Galectin Therapeutics Inc | $267M | — | — | 12 |
| 269 | ADAG | Adagene Inc | $260M | — | — | 8 |
| 270 | PRQR | ProQR Therapeutics BV | $244M | — | — | 12 |
| 271 | ACIU | AC Immune Ltd | $243M | — | — | 12 |
| 272 | TARA | Protara Therapeutics Inc | $243M | — | — | 12 |
| 273 | NAUT | Nautilus Biotechnology Inc | $240M | — | — | 8 |
| 274 | OBIO | Orchestra BioMed Holdings Inc. | $239M | — | — | 6 |
| 275 | KPTI | Karyopharm Therapeutics Inc | $238M | — | — | 12 |
| 276 | CHRS | Coherus BioSciences Inc | $238M | — | — | 12 |
| 277 | KROS | Keros Therapeutics Inc | $234M | — | — | 8 |
| 278 | AVXL | Anavex Life Sciences Corp | $232M | — | — | 12 |
| 279 | IVVD | Invivyd Inc. | $231M | — | — | 6 |
| 280 | CAMP | CAMP4 THERAPEUTICS CORPORATION | $229M | — | — | 12 |
| 281 | DTIL | Precision BioSciences Inc | $226M | — | — | 10 |
| 282 | BDSX | Biodesix Inc | $222M | — | — | 8 |
| 283 | NERV | Minerva Neurosciences Inc | $220M | — | — | 12 |
| 284 | NBP | NovaBridge Biosciences | $220M | — | — | 9 |
| 285 | QTTB | Q32 Bio Inc | $213M | 5.1 | — | 10 |
| 286 | RNA | Atrium Therapeutics, Inc. Common Stock | $213M | — | — | 11 |
| 287 | NKTX | Nkarta Inc | $212M | — | — | 8 |
| 288 | KRRO | Korro Bio, Inc. | $210M | — | — | 9 |
| 289 | VYGR | Voyager Therapeutics Inc | $208M | — | — | 12 |
| 290 | ANIK | Anika Therapeutics Inc | $208M | — | — | 12 |
| 291 | IMUX | Immunic Inc | $201M | — | — | 12 |
| 292 | TNXP | Tonix Pharmaceuticals Holding Corp | $200M | — | — | 12 |
| 293 | ARCT | Arcturus Therapeutics Holdings Inc | $198M | — | — | 12 |
| 294 | WHWK | Whitehawk Therapeutics, Inc. | $196M | — | — | 7 |
| 295 | QSI | QuantumSi Inc | $192M | — | — | 7 |
| 296 | CRBU | Caribou Biosciences Inc | $191M | — | — | 7 |
| 297 | DERM | Journey Medical Corp | $190M | — | — | 12 |
| 298 | ABOS | Acumen Pharmaceuticals Inc | $190M | — | — | 7 |
| 299 | OTLK | OUTLOOK THERAPEUTICS INC | $190M | — | — | 12 |
| 300 | TNYA | Tenaya Therapeutics Inc | $189M | — | — | 7 |
| 301 | HUMA | Humacyte Inc | $187M | — | — | 7 |
| 302 | PLX | Protalix Biotherapeutics Inc | $186M | 12.2 | — | 12 |
| 303 | EQ | Equillium Inc | $184M | — | — | 9 |
| 304 | ACOG | Alpha Cognition Inc | $183M | — | — | 8 |
| 305 | CRBP | Corbus Pharmaceuticals Holding | $179M | — | — | 12 |
| 306 | NRXP | NRX Pharmaceuticals Inc | $179M | — | — | 9 |
| 307 | ALEC | Alector Inc | $179M | — | — | 10 |
| 308 | LFCR | Lifecore Biomedical Inc. | $176M | — | — | 12 |
| 309 | LENZ | LENZ Therapeutics Inc | $175M | — | — | 7 |
| 310 | OKUR | OnKure Therapeutics, Inc. | $173M | — | — | 6 |
| 311 | PYXS | Pyxis Oncology Inc | $169M | — | — | 7 |
| 312 | IPHA | Innate Pharma | $168M | — | — | 12 |
| 313 | MENS | Jyong Biotech Ltd. Ordinary Shares | $168M | — | — | 6 |
| 314 | ANTX | AN2 Therapeutics Inc | $167M | — | — | 7 |
| 315 | ADCT | ADC Therapeutics SA | $164M | — | — | 9 |
| 316 | CBUS | Cibus Global LLC | $164M | — | — | 11 |
| 317 | PEPG | PepGen Ltd | $159M | — | — | 7 |
| 318 | CNTB | Connect Biopharma Holdings Ltd | $158M | — | — | 8 |
| 319 | TLSA | Tiziana Life Sciences Ltd | $157M | — | — | 12 |
| 320 | KZIA | Kazia Therapeutics Ltd ADR | $155M | — | — | 12 |
| 321 | CUE | Cue Biopharma | $154M | — | — | 11 |
| 322 | HURA | TuHURA Biosciences Inc | $152M | — | — | 12 |
| 323 | MOLN | Molecular Partners AG ADR | $151M | — | — | 12 |
| 324 | UNCY | Unicycive Therapeutics Inc | $143M | — | — | 8 |
| 325 | AGEN | Agenus Inc | $140M | 1.6 | — | 12 |
| 326 | ARMP | Armata Pharmaceuticals Inc | $138M | — | — | 12 |
| 327 | SPRB | Spruce Biosciences, Inc. Common Stock | $138M | — | — | 8 |
| 328 | GNLX | Genelux Corporation Common Stock | $134M | — | — | 7 |
| 329 | VXRT | Vaxart Inc | $133M | 3.4 | — | 12 |
| 330 | VTVT | vTv Therapeutics Inc | $132M | — | — | 12 |
| 331 | VANI | Vivani Medical Inc. | $128M | — | — | 12 |
| 332 | PMN | ProMIS Neurosciences Inc. | $128M | — | — | 12 |
| 333 | ENGN | enGene Holdings Inc. Common Stock | $127M | — | — | 6 |
| 334 | LIXT | Lixte Biotechnology Holdings Inc | $125M | — | — | 12 |
| 335 | RCEL | Avita Medical Ltd | $125M | — | — | 12 |
| 336 | ALDX | Aldeyra The | $125M | — | — | 12 |
| 337 | BNR | Burning Rock Biotech Ltd | $123M | — | — | 9 |
| 338 | COYA | Coya Therapeutics, Inc. Common Stock | $123M | — | — | 6 |
| 339 | SPRO | Spero Therapeutics Inc | $123M | 8.2 | — | 11 |
| 340 | CRDL | Cardiol Therapeutics Inc Class A | $116M | — | — | 9 |
| 341 | FBIO | Fortress Biotech Inc | $110M | 1.0 | — | 12 |
| 342 | BDTX | Black Diamond Therapeutics Inc | $109M | — | — | 9 |
| 343 | XGN | Exagen Inc | $108M | — | — | 12 |
| 344 | ONCY | Oncolytics Biotech Inc | $106M | — | — | 12 |
| 345 | KLRS | Kalaris Therapeutics, Inc. | $106M | — | — | 8 |
| 346 | ANIX | Anixa Biosciences Inc | $104M | — | — | 12 |
| 347 | PYPD | PolyPid | $100M | — | — | 12 |
| 348 | ICCC | ImmuCell Corporation | $98.5M | — | — | 12 |
| 349 | ATHE | Alterity Therapeutics Ltd | $98.4M | — | — | 12 |
| 350 | CGTX | Cognition Therapeutics Inc | $97.6M | — | — | 7 |
| 351 | INO | Inovio Pharmaceuticals Inc | $97.1M | — | — | 12 |
| 352 | BMEA | Biomea Fusion Inc | $95.4M | — | — | 7 |
| 353 | RANI | Rani Therapeutics Holdings Inc | $94.5M | — | — | 7 |
| 354 | RLYB | Rallybio Corp | $91.2M | — | — | 7 |
| 355 | CRDF | Cardiff Oncology Inc | $90.9M | — | — | 12 |
| 356 | OKYO | OKYO Pharma Ltd ADR | $88.7M | — | — | 12 |
| 357 | ATRA | Atara Biotherapeutics Inc | $87.9M | — | — | 12 |
| 358 | GOSS | Gossamer Bio Inc | $85.5M | — | — | 10 |
| 359 | RNTX | Rein Therapeutics Inc | $85.4M | — | — | 6 |
| 360 | NRXS | Neuraxis, Inc. | $84M | — | — | 6 |
| 361 | ACRV | Acrivon Therapeutics, Inc. Common Stock | $83.9M | — | — | 6 |
| 362 | ENTX | Entera Bio Ltd | $81.6M | — | — | 11 |
| 363 | MAIA | MAIA Biotechnology Inc. | $80.9M | — | — | 7 |
| 364 | CLNN | Clene Inc. | $80.1M | — | — | 9 |
| 365 | ANVS | Annovis Bio Inc | $79.1M | — | — | 12 |
| 366 | HRTX | Heron Therapeuti | $78.4M | — | — | 12 |
| 367 | SERA | Sera Prognostics Inc | $77.1M | — | — | 7 |
| 368 | GANX | Gain Therapeutics Inc | $76.8M | — | — | 8 |
| 369 | IBIO | iBio, Inc. Common Stock | $75M | — | — | 12 |
| 370 | CYPH | Cypherpunk Technologies Inc. | $74.8M | — | — | 12 |
| 371 | GNTA | Genenta Science SpA ADR | $72.3M | — | — | 7 |
| 372 | TCRX | Tscan Therapeutics Inc | $71.2M | — | — | 7 |
| 373 | XBIT | XBiotech Inc | $69.8M | — | — | 12 |
| 374 | PLRX | Pliant Therapeutics Inc | $69.4M | — | — | 9 |
| 375 | MNOV | MediciNova Inc | $68.4M | — | — | 12 |
| 376 | EDSA | Edesa Biotech Inc | $67.5M | — | — | 12 |
| 377 | OSTX | OS Therapies Incorporated | $66.8M | — | — | 6 |
| 378 | IMA | ImageneBio, Inc. | $66.7M | — | — | 8 |
| 379 | CING | Cingulate Inc | $66.1M | — | — | 7 |
| 380 | PMVP | Pmv Pharmaceuticals Inc | $66.1M | — | — | 8 |
| 381 | EXOZ | eXoZymes, Inc. | $64.7M | — | — | 5 |
| 382 | IMMP | Immutep Ltd ADR | $61.7M | — | — | 12 |
| 383 | XLO | Xilio Development Inc | $59.8M | — | — | 7 |
| 384 | BYSI | BeyondSpring Inc | $59.2M | — | — | 12 |
| 385 | MCRB | Seres Therapeutics Inc | $59.2M | — | — | 12 |
| 386 | INCR | InterCure Ltd. | $55.4M | — | — | 12 |
| 387 | INKT | Mink Therapeutics Inc | $55M | — | — | 7 |
| 388 | BOLD | Boundless Bio, Inc. Common Stock | $54.2M | — | — | 8 |
| 389 | KZR | Kezar Life Sciences Inc | $53.9M | — | — | 10 |
| 390 | ATYR | aTyr Pharma, Inc. | $53.7M | — | — | 12 |
| 391 | TIL | Instil Bio Inc. | $52.2M | — | — | 7 |
| 392 | MREO | Mereo BioPharma Group PLC ADR | $51.7M | — | — | 11 |
| 393 | INMB | INmune Bio Inc | $51.6M | — | — | 11 |
| 394 | SABSW | SAB Biotherapeutics Inc | — | 0.0 | — | 7 |