Spyre Therapeutics, Inc.
SYREAs of the close on Sep 25, 2026
Price
$85.69
Market cap
$7.56B
P/E (diluted TTM)
—
Per-share earnings are not available for each of the last four quarters
EPS (TTM)
—
Per-share earnings are not available for each of the last four quarters
Dividend yield
—
Dividend records do not yet cover the latest payments
Figures shown here come from public SEC filings. Dates beside each section show the available history.
How Spyre Therapeutics, Inc. Makes Money
Follow each dollar of revenue through to what shareholders keep.
From revenue to net income
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Source: Spyre Therapeutics, Inc. — 10-K filed Feb 19, 2026
Financial Summary
Choose a year or quarter, compare it with the same period a year earlier, and open any row for its full filing history.
Loading financial history…
SEC filings supply these figures; updates after the dates shown are not included. This page includes 12 annual periods. The latest annual period ends Dec 31, 2025. The latest insider filing shown is dated Jun 26, 2026. The latest institutional report shown is dated Mar 31, 2026; other ownership filings may exist.
Ownership
Who holds the shares, as reported in SEC ownership filings.
Reported 13F positions
Each row shows what a filer reported for one date, not a current position. The link opens that filing.
| Filer | Report date | Shares | Value | Filing |
|---|---|---|---|---|
| PNC FINANCIAL SERVICES GROUP, INC. | 2026-03-31 | 123 | $6.2K | SEC filing |
| Vanguard Personalized Indexing Management, LLC | 2026-03-31 | 4,397 | $222K | SEC filing |
| ROYAL BANK OF CANADA | 2026-03-31 | 3,250 | $164K | SEC filing |
| Rafferty Asset Management, LLC | 2026-03-31 | 56,920 | $2.87M | SEC filing |
| Keating Financial Advisory Services, Inc. | 2026-03-31 | 4 | $202 | SEC filing |
| Siren, L.L.C. | 2026-03-31 | 818,598 | $41.3M | SEC filing |
| Union Bancaire Privee, UBP SA | 2026-03-31 | 3,880 | $159K | SEC filing |
| SIGNATUREFD, LLC | 2026-03-31 | 70 | $3.53K | SEC filing |
| BRAIDWELL LP | 2026-03-31 | 932,823 | $47.1M | SEC filing |
| NORTHERN TRUST CORP | 2026-03-31 | 578,907 | $29.2M | SEC filing |
| FIRST TRUST ADVISORS LP | 2026-03-31 | 178,389 | $9M | SEC filing |
| XPONANCE LLC | 2026-03-31 | 6,445 | $325K | SEC filing |
| SBI Securities Co., Ltd. | 2026-03-31 | 5 | $252 | SEC filing |
| NEW YORK STATE COMMON RETIREMENT FUND | 2026-03-31 | 22,265 | $1.12M | SEC filing |
| IFP Advisors, Inc | 2026-03-31 | 24 | $1.21K | SEC filing |
| BOOTHBAY FUND MANAGEMENT, LLC | 2026-03-31 | 193,031 | $9.74M | SEC filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2026-03-31 | 28,962 | $1.46M | SEC filing |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 2026-03-31 | 25,799 | Not shown | SEC filing |
| MassMutual Private Wealth & Trust, FSB | 2026-03-31 | 3 | $151 | SEC filing |
| JPMORGAN CHASE & CO | 2026-03-31 | 979,299 | $44.5M | SEC filing |
- Each value is checked against Spyre Therapeutics, Inc.'s share prices from within about three months of its report date (insiders' Form 4 trades and the latest close).
- Value not shown for 1 row: the filed value is about 1,000 times too small for the share count at Spyre Therapeutics, Inc.'s share price.
120 filers have only one report here.
Unusually large insider trades
Each trade is compared with the other insider trades of the same kind in the same security among Spyre Therapeutics, Inc.'s recent filings on file. Size alone is context, not a prediction or evidence of improper trading.
- 2026-06-23 · Harwin Peter Evan: Larger than all 52 other insider sales of Common Stock on file. SEC filing
- 2026-06-22 · HENDERSON MICHAEL THOMAS: Larger than 47 of the 52 other insider sales of Common Stock on file. SEC filing
- 2026-05-08 · HENDERSON MICHAEL THOMAS: Larger than 51 of the 52 other insider sales of Common Stock on file. SEC filing
- 2026-05-08 · HENDERSON MICHAEL THOMAS: Larger than 49 of the 52 other insider sales of Common Stock on file. SEC filing
- 2026-05-01 · Sloan Sheldon: Larger than 48 of the 52 other insider sales of Common Stock on file. SEC filing
- 2025-11-03 · Turtle Cameron: Larger than 50 of the 52 other insider sales of Common Stock on file. SEC filing
- 2022-08-25 · Souza Marcio: Larger than 26 of the 28 other insider purchases of Common Stock on file. SEC filing
- 2021-12-09 · Shanafelt Armen: Larger than 27 of the 28 other insider purchases of Common Stock on file. SEC filing
- 2020-04-30 · Quinn Anthony G.: Larger than all 28 other insider purchases of Common Stock on file. SEC filing
Independent insiders buying near the same time
- 2022-03-11–2022-03-16: 5 event(s) across 2 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing )
- 2021-12-09–2021-12-13: 6 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing , filing )
Purchases & sales (open market or private)
| Security | Code | Price | Filing | |||
|---|---|---|---|---|---|---|
| 2026-06-25 | Burrows Scott L · Chief Financial Officer | Common Stock | S — Open market or private sale | −10,000 | 87.14 | SEC filing |
| 2026-06-25 | Burrows Scott L · Chief Financial Officer | Common Stock | S — Open market or private sale | −5,000 | 87.12 | SEC filing |
| 2026-06-23 | Harwin Peter Evan · Director | Common Stock | S — Open market or private sale | −4,684,781 | 85.31 | SEC filing |
| 2026-06-22 | HENDERSON MICHAEL THOMAS · Director | Common Stock | S — Open market or private sale | −20,000 | 100.00 | SEC filing |
| 2026-06-03 | Sloan Sheldon · Chief Medical Officer | Common Stock | S — Open market or private sale | −8,333 | 75.00 | SEC filing |
| 2026-06-01 | Turtle Cameron · Chief Executive Officer | Common Stock | S — Open market or private sale | −8,149 | 70.50 | SEC filing |
| 2026-06-01 | Turtle Cameron · Chief Executive Officer | Common Stock | S — Open market or private sale | −3,294 | 71.38 | SEC filing |
| 2026-06-01 | Turtle Cameron · Chief Executive Officer | Common Stock | S — Open market or private sale | −3,557 | 69.40 | SEC filing |
Showing 8 of 20 rows
Grants, exercises, tax & gifts
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-06-25 | Burrows Scott L · Chief Financial Officer | Stock Option (Right to Buy) | M — Exercise or conversion of derivative security | −15,000 | SEC filing |
| 2026-06-25 | Burrows Scott L · Chief Financial Officer | Common Stock | M — Exercise or conversion of derivative security | +15,000 | SEC filing |
| 2026-06-23 | Harwin Peter Evan · Director | Series B Preferred Stock | C — Conversion of derivative security | −16,667 | SEC filing |
| 2026-06-23 | Harwin Peter Evan · Director | Common Stock | C — Conversion of derivative security | +666,680 | SEC filing |
| 2026-06-03 | Sloan Sheldon · Chief Medical Officer | Stock Option (Right to Buy) | M — Exercise or conversion of derivative security | −8,333 | SEC filing |
| 2026-06-03 | Sloan Sheldon · Chief Medical Officer | Common Stock | M — Exercise or conversion of derivative security | +8,333 | SEC filing |
| 2026-06-01 | Burrows Scott L · Chief Financial Officer | Common Stock | M — Exercise or conversion of derivative security | +7,500 | SEC filing |
| 2026-06-01 | Burrows Scott L · Chief Financial Officer | Stock Option (Right to Buy) | M — Exercise or conversion of derivative security | −7,500 | SEC filing |
Showing 8 of 28 rows
Other activity
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-01-21 | HENDERSON MICHAEL THOMAS · Director | Common Stock | J — Other acquisition or disposition | +63,227 | SEC filing |
| 2025-01-10 | HENDERSON MICHAEL THOMAS · Director | Common Stock | J — Other acquisition or disposition | +105,379 | SEC filing |
| 2023-12-29 | Harwin Peter Evan · Director, 10% owner | Common Stock | J — Other acquisition or disposition | +406,038 | SEC filing |
| 2023-12-29 | Harwin Peter Evan · Director, 10% owner | Common Stock | J — Other acquisition or disposition | −3,435,480 | SEC filing |
Showing 4 of 4 rows
These tables describe filed transactions, not current holdings. Prices are shown as filed; a currency is added only when the filing's data names one. Amended and possible duplicate rows are left out of size comparisons and transaction groups.