Ionis Pharmaceuticals Inc
IONSAs of the close on Sep 25, 2026
Price
$44.50
Market cap
$7.4B
P/E (diluted TTM)
—
Not meaningful: the last four quarters were a loss
EPS (TTM)
−$3.46
Four quarters to Jun 30, 2026
Dividend yield
—
Dividend records do not yet cover the latest payments
Figures shown here come from public SEC filings. Dates beside each section show the available history.
How Ionis Pharmaceuticals Inc Makes Money
Follow each dollar of revenue through to what shareholders keep.
From revenue to net income
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Financial Summary
Choose a year or quarter, compare it with the same period a year earlier, and open any row for its full filing history.
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SEC filings supply these figures; updates after the dates shown are not included. This page includes 18 annual periods. The latest annual period ends Dec 31, 2025. The latest insider filing shown is dated Jun 30, 2026. The latest institutional report shown is dated Mar 31, 2026; other ownership filings may exist.
Ownership
Who holds the shares, as reported in SEC ownership filings.
Reported 13F positions
Each row shows what a filer reported for one date, not a current position. The link opens that filing.
| Filer | Report date | Shares | Value | Filing |
|---|---|---|---|---|
| Virtu Financial LLC | 2026-03-31 | 5,342 | Not shown | SEC filing |
| MERCER GLOBAL ADVISORS INC /ADV | 2026-03-31 | 6,296 | $473K | SEC filing |
| HANTZ FINANCIAL SERVICES, INC. | 2026-03-31 | 36 | Not shown | SEC filing |
| Swiss Life Asset Management Ltd | 2026-03-31 | 9,175 | $689K | SEC filing |
| SG Americas Securities, LLC | 2026-03-31 | 63,295 | Not shown | SEC filing |
| 3 FACTOR INDEXING, LLC | 2026-03-31 | 2 | $151 | SEC filing |
| GSA CAPITAL PARTNERS LLP | 2026-03-31 | 3,172 | Not shown | SEC filing |
| FMR LLC | 2026-03-31 | 24,556,637 | $1.84B | SEC filing |
| Horizon Investments, LLC | 2026-03-31 | 48 | $3.6K | SEC filing |
| ALLSTATE CORP | 2026-03-31 | 20,565 | $1.54M | SEC filing |
| BAKER BROS. ADVISORS LP | 2026-03-31 | 2,047,727 | $154M | SEC filing |
| North Dakota State Investment Board | 2026-03-31 | 4,623 | $347K | SEC filing |
| Sachetta, LLC | 2026-03-31 | 45 | $3.38K | SEC filing |
| Strategic Wealth Partners, Ltd. | 2026-03-31 | 150 | $11.3K | SEC filing |
| ADAR1 Capital Management, LLC | 2026-03-31 | 160,338 | $12M | SEC filing |
| Ascentis Wealth Management, LLC | 2026-03-31 | 400 | $30K | SEC filing |
| INTRUST BANK NA | 2026-03-31 | 4,056 | $305K | SEC filing |
| WELLS FARGO & COMPANY/MN | 2026-03-31 | 189,853 | $14.3M | SEC filing |
| CITADEL ADVISORS LLC | 2026-03-31 | 942,534 | $70.8M | SEC filing |
| Pinnacle Wealth Planning Services, Inc. | 2026-03-31 | 4,213 | $316K | SEC filing |
- Each value is checked against Ionis Pharmaceuticals Inc's share prices from within about three months of its report date (insiders' Form 4 trades and the latest close).
- Value not shown for 4 rows: the filed value is about 1,000 times too small for the share count at Ionis Pharmaceuticals Inc's share price.
120 filers have only one report here.
Unusually large insider trades
Each trade is compared with the other insider trades of the same kind in the same security among Ionis Pharmaceuticals Inc's recent filings on file. Size alone is context, not a prediction or evidence of improper trading.
- 2026-06-26 · Monia Brett P: Larger than 78 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-06-12 · Kordasiewicz Holly B.: Larger than 76 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-05-04 · LOSCALZO JOSEPH: Larger than 79 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-03-16 · HOUGEN ELIZABETH L: Larger than all 83 other insider sales of Common Stock on file. SEC filing
- 2026-03-09 · Monia Brett P: Larger than 82 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-03-03 · Diaz Allene M.: Larger than 75 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-03-03 · BENNETT C FRANK: Larger than 81 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-02-02 · BENNETT C FRANK: Larger than 77 of the 83 other insider sales of Common Stock on file. SEC filing
- 2026-01-30 · Monia Brett P: Larger than 80 of the 83 other insider sales of Common Stock on file. SEC filing
Purchases & sales (open market or private)
| Security | Code | Price | Filing | |||
|---|---|---|---|---|---|---|
| 2026-06-26 | Schneider Eugene · EVP, Chf Clinical Develop Ofcr | Common Stock | S — Open market or private sale | −26,000 | 81.05 | SEC filing |
| 2026-06-26 | Baroldi Joseph · EVP, Chief Business Officer | Common Stock | S — Open market or private sale | −5,635 | 80.16 | SEC filing |
| 2026-06-26 | O'NEIL PATRICK R. · EVP CLO & General Counsel | Common Stock | S — Open market or private sale | −3,069 | 80.00 | SEC filing |
| 2026-06-26 | Monia Brett P · Chief Executive Officer | Common Stock | S — Open market or private sale | −50,000 | 80.59 | SEC filing |
| 2026-06-25 | Swayze Eric · EVP Research | Common Stock | S — Open market or private sale | −10,602 | 79.18 | SEC filing |
| 2026-06-25 | Monia Brett P · Chief Executive Officer | Common Stock | S — Open market or private sale | −21,072 | 78.49 | SEC filing |
| 2026-06-24 | Monia Brett P · Chief Executive Officer | Common Stock | S — Open market or private sale | −14,565 | 78.41 | SEC filing |
| 2026-06-15 | BERTHELSEN SPENCER R · Director | Common Stock | S — Open market or private sale | −8,000 | 73.49 | SEC filing |
Showing 8 of 10 rows
Grants, exercises, tax & gifts
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-06-26 | Schneider Eugene · EVP, Chf Clinical Develop Ofcr | Common Stock | M — Exercise or conversion of derivative security | +26,000 | SEC filing |
| 2026-06-26 | Monia Brett P · Chief Executive Officer | Common Stock | M — Exercise or conversion of derivative security | +50,000 | SEC filing |
| 2026-06-26 | Baroldi Joseph · EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | M — Exercise or conversion of derivative security | −1,769 | SEC filing |
| 2026-06-26 | Schneider Eugene · EVP, Chf Clinical Develop Ofcr | Non-Qualified Stock Option (right to buy) | M — Exercise or conversion of derivative security | −26,000 | SEC filing |
| 2026-06-26 | Baroldi Joseph · EVP, Chief Business Officer | Common Stock | M — Exercise or conversion of derivative security | +3,866 | SEC filing |
| 2026-06-26 | Monia Brett P · Chief Executive Officer | Non-Qualified Stock Option (right to buy) | M — Exercise or conversion of derivative security | −50,000 | SEC filing |
| 2026-06-26 | Baroldi Joseph · EVP, Chief Business Officer | Common Stock | M — Exercise or conversion of derivative security | +1,769 | SEC filing |
| 2026-06-26 | Baroldi Joseph · EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | M — Exercise or conversion of derivative security | −3,866 | SEC filing |
Showing 8 of 20 rows
Other activity
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-02-27 | Monia Brett P · Chief Executive Officer | Common Stock | J — Other acquisition or disposition | +484 | SEC filing |
| 2026-02-27 | O'NEIL PATRICK R. · EVP CLO & General Counsel | Common Stock | J — Other acquisition or disposition | +376 | SEC filing |
| 2026-02-27 | Birchler Brian · EVP, Corp and Development Ops | Common Stock | J — Other acquisition or disposition | +351 | SEC filing |
| 2026-02-27 | Swayze Eric · EVP Research | Common Stock | J — Other acquisition or disposition | +256 | SEC filing |
| 2026-02-27 | BENNETT C FRANK · EVP, Chief Scientific Officer | Common Stock | J — Other acquisition or disposition | +261 | SEC filing |
| 2026-02-02 (amended) | BENNETT C FRANK · EVP, Chief Scientific Officer | Common Stock | J — Other acquisition or disposition | −0 | SEC filing |
Showing 6 of 6 rows
These tables describe filed transactions, not current holdings. Prices are shown as filed; a currency is added only when the filing's data names one. Amended and possible duplicate rows are left out of size comparisons and transaction groups.