Prelude Therapeutics Inc
PRLDAs of the close on Sep 25, 2026
Price
$3.88
Market cap
—
The cover-page share count does not match the latest report's share count
P/E (diluted TTM)
—
The fourth quarter's per-share figure could not be confirmed from the annual report
EPS (TTM)
—
The fourth quarter's per-share figure could not be confirmed from the annual report
Dividend yield
—
Dividend records do not yet cover the latest payments
Figures shown here come from public SEC filings. Dates beside each section show the available history.
How Prelude Therapeutics Inc Makes Money
Follow each dollar of revenue through to what shareholders keep.
From revenue to net income
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Financial Summary
Choose a year or quarter, compare it with the same period a year earlier, and open any row for its full filing history.
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SEC filings supply these figures; updates after the dates shown are not included. This page includes 7 annual periods. The latest annual period ends Dec 31, 2025. The latest insider filing shown is dated Jun 10, 2026. The latest institutional report shown is dated Mar 31, 2026; other ownership filings may exist.
Ownership
Who holds the shares, as reported in SEC ownership filings.
Reported 13F positions
Each row shows what a filer reported for one date, not a current position. The link opens that filing.
| Filer | Report date | Shares | Value | Filing |
|---|---|---|---|---|
| TWO SIGMA INVESTMENTS, LP | 2026-03-31 | 923,626 | $3.16M | SEC filing |
| UBS Group AG | 2026-03-31 | 64,505 | $221K | SEC filing |
| MARSHALL WACE, LLP | 2026-03-31 | 358,906 | $1.23M | SEC filing |
| PRUDENTIAL FINANCIAL INC | 2026-03-31 | 17,420 | $59.6K | SEC filing |
| NISA INVESTMENT ADVISORS, LLC | 2026-03-31 | 1,634 | $5.59K | SEC filing |
| HRT FINANCIAL LP | 2026-03-31 | 58,699 | Not shown | SEC filing |
| SBI Securities Co., Ltd. | 2026-03-31 | 2,641 | $9.03K | SEC filing |
| NORTHERN TRUST CORP | 2026-03-31 | 50,120 | $171K | SEC filing |
| ORBIMED ADVISORS LLC | 2026-03-31 | 10,909,256 | $37.3M | SEC filing |
| Point72 Asset Management, L.P. | 2026-03-31 | 16,329 | $55.8K | SEC filing |
| CITIGROUP INC | 2026-03-31 | 5 | $17 | SEC filing |
| STATE STREET CORP | 2026-03-31 | 138,231 | $473K | SEC filing |
| ROYAL BANK OF CANADA | 2026-03-31 | 2,331 | $8K | SEC filing |
| XTX Topco Ltd | 2026-03-31 | 57,190 | $196K | SEC filing |
| BlackRock, Inc. | 2026-03-31 | 321,886 | $1.1M | SEC filing |
| GEODE CAPITAL MANAGEMENT, LLC | 2026-03-31 | 302,458 | $1.03M | SEC filing |
| Kynam Capital Management, LP | 2026-03-31 | 1,592,551 | $5.45M | SEC filing |
| Diametric Capital, LP | 2026-03-31 | 11,980 | $41K | SEC filing |
| Cerity Partners LLC | 2026-03-31 | 32,875 | $112K | SEC filing |
| JANE STREET GROUP, LLC | 2026-03-31 | 192,963 | $660K | SEC filing |
- Each value is checked against Prelude Therapeutics Inc's share prices from within about three months of its report date (insiders' Form 4 trades and the latest close).
- Value not shown for 1 row: the filed value is about 1,000 times too small for the share count at Prelude Therapeutics Inc's share price.
Filer report history
Two reports per filer, as filed. No change is calculated, because the data on file cannot confirm that both reports describe the same security.
- RENAISSANCE TECHNOLOGIES LLC: 271,300 shares reported 2025-12-31; 275,200 shares reported 2026-03-31.
- CWM, LLC: 692 shares reported 2025-12-31; 573 shares reported 2026-03-31.
- MILLENNIUM MANAGEMENT LLC: 150,997 shares reported 2025-12-31; 382,737 shares reported 2026-03-31.
- CALDWELL SUTTER CAPITAL, INC.: 2,000 shares reported 2025-12-31; 1,000 shares reported 2026-03-31.
- Connor, Clark & Lunn Investment Management Ltd.: 46,090 shares reported 2025-12-31; 109,085 shares reported 2026-03-31.
- OMERS ADMINISTRATION Corp: 73,000 shares reported 2025-12-31; 32,700 shares reported 2026-03-31.
- SUSQUEHANNA INTERNATIONAL GROUP, LLP: 135,909 shares reported 2025-12-31; 267,788 shares reported 2026-03-31.
- ACADIAN ASSET MANAGEMENT LLC: 535,703 shares reported 2025-12-31; 511,519 shares reported 2026-03-31.
- BRIDGEWAY CAPITAL MANAGEMENT, LLC: 53,500 shares reported 2025-12-31; 53,500 shares reported 2026-03-31.
- BANK OF AMERICA CORP /DE/: 9,808 shares reported 2025-12-31; 56,525 shares reported 2026-03-31.
- SPHERA FUNDS MANAGEMENT LTD.: 122,752 shares reported 2025-12-31; 558,339 shares reported 2026-03-31.
- GROUP ONE TRADING LLC: 500 shares reported 2025-12-31; 3,907 shares reported 2026-03-31.
Showing the 12 most recent filer reports.
16 filers have only one report here.
Unusually large insider trades
Each trade is compared with the other insider trades of the same kind in the same security among Prelude Therapeutics Inc's recent filings on file. Size alone is context, not a prediction or evidence of improper trading.
- 2026-04-21 · ORBIMED ADVISORS LLC: Larger than 29 of the 30 other insider purchases of Common Stock on file. SEC filing
- 2026-04-21 · Bonita David P: Larger than 27 of the 30 other insider purchases of Common Stock on file. SEC filing
- 2026-04-21 · Bonita David P: Larger than 29 of the 30 other insider purchases of Common Stock on file. SEC filing
- 2026-04-21 · ORBIMED ADVISORS LLC: Larger than 27 of the 30 other insider purchases of Common Stock on file. SEC filing
- 2021-12-15 · Morosini Deborah: Larger than all 49 other insider sales of Common Stock on file. SEC filing
- 2021-11-16 · Morosini Deborah: Larger than 48 of the 49 other insider sales of Common Stock on file. SEC filing
- 2021-07-27 · Scherle Peggy: Larger than 46 of the 49 other insider sales of Common Stock on file. SEC filing
- 2021-04-27 · Mauro David J: Larger than 45 of the 49 other insider sales of Common Stock on file. SEC filing
- 2021-04-19 · Mauro David J: Larger than 47 of the 49 other insider sales of Common Stock on file. SEC filing
Independent insiders buying near the same time
- 2026-04-21–2026-04-21: 4 event(s) across 2 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing )
- 2025-03-20–2025-03-25: 4 event(s) across 2 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing )
- 2024-12-23–2024-12-30: 2 event(s) across 2 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing )
- 2024-12-18–2024-12-23: 5 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing )
- 2023-05-22–2023-05-25: 7 event(s) across 5 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing , filing , filing )
Purchases & sales (open market or private)
| Security | Code | Price | Filing | |||
|---|---|---|---|---|---|---|
| 2026-04-21 | ORBIMED ADVISORS LLC · Director, 10% owner | Common Stock | P — Open market or private purchase | +1,126,126 | 4.44 | SEC filing |
| 2026-04-21 | BAKER JULIAN · Director, 10% owner | Warrants to purchase Common Stock | P — Open market or private purchase | +2,137,651 | 4.44 | SEC filing |
| 2026-04-21 | Bonita David P · Director, 10% owner | Common Stock | P — Open market or private purchase | +1,689,189 | 4.44 | SEC filing |
| 2026-04-21 | Bonita David P · Director, 10% owner | Common Stock | P — Open market or private purchase | +1,126,126 | 4.44 | SEC filing |
| 2026-04-21 | BAKER JULIAN · Director, 10% owner | Warrants to purchase Common Stock | P — Open market or private purchase | +114,601 | 4.44 | SEC filing |
| 2026-04-21 | ORBIMED ADVISORS LLC · Director, 10% owner | Common Stock | P — Open market or private purchase | +1,689,189 | 4.44 | SEC filing |
| 2025-03-25 | Combs Andrew · Chief Chemistry Officer | Common Stock | P — Open market or private purchase | +100,000 | 0.69 | SEC filing |
| 2025-03-25 | Vaddi Krishna · CEO | Common Stock | P — Open market or private purchase | +675,000 | 0.69 | SEC filing |
Showing 8 of 20 rows
Grants, exercises, tax & gifts
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-06-09 | FRIEDMAN PAUL A · Director | Director Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +38,000 | SEC filing |
| 2026-06-09 | Sandor Victor · Director | Director Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +38,000 | SEC filing |
| 2026-06-09 | Babler Martin · Director | Director Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +38,000 | SEC filing |
| 2026-06-09 | BAKER JULIAN · Director, 10% owner | Non-Qualified Stock Option (right to buy) | A — Grant, award, or other acquisition | +38,000 | SEC filing |
| 2026-06-09 | Bonita David P · Director, 10% owner | Director Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +38,000 | SEC filing |
| 2026-06-09 | Dorton Katina · Director | Director Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +38,000 | SEC filing |
| 2026-05-01 | Morris Charles Q · Chief Medical Officer | Employee Stock Option (right to buy) | A — Grant, award, or other acquisition | +450,000 | SEC filing |
| 2026-02-04 | Combs Andrew · Chief Chemistry Officer | Employee Stock Option (right to buy) | A — Grant, award, or other acquisition | +230,000 | SEC filing |
Showing 8 of 29 rows
Other activity
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-04-27 | RA Capital Healthcare Fund LP · 10% owner | Common Stock | J — Other acquisition or disposition | −1,407,000 | SEC filing |
| 2026-04-27 | RA Capital Healthcare Fund LP · 10% owner | Pre-Funded Warrants (Right to Buy) | J — Other acquisition or disposition | +1,407,000 | SEC filing |
Showing 2 of 2 rows
These tables describe filed transactions, not current holdings. Prices are shown as filed; a currency is added only when the filing's data names one. Amended and possible duplicate rows are left out of size comparisons and transaction groups.