Upstream Bio, Inc.
UPBFigures shown here come from public SEC filings. Dates beside each section show the available history.
How Upstream Bio, Inc. Makes Money
Follow each dollar of revenue through to what shareholders keep.
From revenue to net income
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Financial Summary
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SEC filings supply these figures; updates after the dates shown are not included. This page includes 3 annual periods. The latest annual period ends Dec 31, 2025. The latest insider filing shown is dated Jun 17, 2026. The latest institutional report shown is dated Mar 31, 2026; other ownership filings may exist.
Ownership
Who holds the shares, as reported in SEC ownership filings.
Reported 13F positions
Each row shows what a filer reported for one date, not a current position. The link opens that filing.
| Filer | Report date | Shares | Value | Filing |
|---|---|---|---|---|
| KLP KAPITALFORVALTNING AS | 2026-03-31 | 5,900 | $53.1K | SEC filing |
| Parallel Advisors, LLC | 2026-03-31 | 2 | $18 | SEC filing |
| AXQ CAPITAL, LP | 2026-03-31 | 27,503 | $248K | SEC filing |
| Ameritas Advisory Services, LLC | 2026-03-31 | 31 | $279 | SEC filing |
| Allworth Financial LP | 2026-03-31 | 263 | $2.37K | SEC filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2026-03-31 | 15,961 | $144K | SEC filing |
| MARSHALL WACE, LLP | 2026-03-31 | 66,770 | $601K | SEC filing |
| FMR LLC | 2026-03-31 | 8,101,563 | $72.9M | SEC filing |
| STATE STREET CORP | 2026-03-31 | 705,350 | $6.35M | SEC filing |
| MARTINGALE ASSET MANAGEMENT L P | 2026-03-31 | 26,223 | $236K | SEC filing |
| AQR CAPITAL MANAGEMENT LLC | 2026-03-31 | 72,171 | $650K | SEC filing |
| Police & Firemen's Retirement System of New Jersey | 2026-03-31 | 9,456 | $85.1K | SEC filing |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2026-03-31 | 588 | $5.29K | SEC filing |
| DEUTSCHE BANK AG\ | 2026-03-31 | 180,889 | $1.63M | SEC filing |
| Schonfeld Strategic Advisors LLC | 2026-03-31 | 161,349 | $1.45M | SEC filing |
| XTX Topco Ltd | 2026-03-31 | 209,277 | $1.88M | SEC filing |
| OSAIC HOLDINGS, INC. | 2026-03-31 | 389 | $3.5K | SEC filing |
| SAMSARA BIOCAPITAL, LLC | 2026-03-31 | 736,047 | $6.62M | SEC filing |
| Man Group plc | 2026-03-31 | 21,154 | $190K | SEC filing |
| Corient Private Wealth LLC | 2026-03-31 | 12,157 | $109K | SEC filing |
120 filers have only one report here.
Unusually large insider trades
Each trade is compared with the other insider trades of the same kind in the same security among Upstream Bio, Inc.'s recent filings on file. Size alone is context, not a prediction or evidence of improper trading.
- 2026-06-16 · Sutherland Everett Rand: Larger than all 9 other insider sales of Common Stock on file. SEC filing
Independent insiders buying near the same time
Purchases & sales (open market or private)
| Security | Code | Price | Filing | |||
|---|---|---|---|---|---|---|
| 2026-06-16 | GRAY MICHAEL · CFO and COO | Common Stock | S — Open market or private sale | −853 | 6.10 | SEC filing |
| 2026-06-16 | Deykin Aaron · Chief Medical Officer | Common Stock | S — Open market or private sale | −895 | 6.10 | SEC filing |
| 2026-06-16 | Ambrose Allison · General Counsel | Common Stock | S — Open market or private sale | −477 | 6.10 | SEC filing |
| 2026-06-16 | Houghton Adam · Chief Business Officer | Common Stock | S — Open market or private sale | −700 | 6.10 | SEC filing |
| 2026-06-16 | Sutherland Everett Rand · Chief Executive Officer | Common Stock | S — Open market or private sale | −2,095 | 6.10 | SEC filing |
| 2026-03-16 | Sutherland Everett Rand · Chief Executive Officer | Common Stock | S — Open market or private sale | −2,093 | 9.29 | SEC filing |
| 2026-03-16 | Houghton Adam · Chief Business Officer | Common Stock | S — Open market or private sale | −699 | 9.29 | SEC filing |
| 2026-03-16 | Ambrose Allison · General Counsel | Common Stock | S — Open market or private sale | −475 | 9.29 | SEC filing |
Showing 8 of 15 rows
Grants, exercises, tax & gifts
| Security | Code | Filing | |||
|---|---|---|---|---|---|
| 2026-06-09 | Chimovits Erez · Director | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +17,096 | SEC filing |
| 2026-06-09 | Ratcliffe Liam · Director | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +17,096 | SEC filing |
| 2026-06-09 | Beckman Daniella · Director | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +17,096 | SEC filing |
| 2026-06-09 | Ruddy Marcella K. · Director | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +17,096 | SEC filing |
| 2026-06-09 | Renaud Ronald C JR · Director | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +17,096 | SEC filing |
| 2026-06-09 | Fleming Harold Edward · Director | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +17,096 | SEC filing |
| 2026-01-02 | Deykin Aaron · Chief Medical Officer | Stock Option (Right to Buy) | A — Grant, award, or other acquisition | +96,000 | SEC filing |
| 2026-01-02 | Ambrose Allison · General Counsel | Common Stock | A — Grant, award, or other acquisition | +17,000 | SEC filing |
Showing 8 of 20 rows
These tables describe filed transactions, not current holdings. Prices are shown as filed; a currency is added only when the filing's data names one. Amended and possible duplicate rows are left out of size comparisons and transaction groups.