Septerna, Inc.

SEPN
As of the close on Sep 25, 2026
Price
$37.77
Market cap
$1.76B
P/E (diluted TTM)
—
Not meaningful: the last four quarters were a loss
EPS (TTM)
−$0.53
Four quarters to Jun 30, 2026
Dividend yield
—
Dividend records do not yet cover the latest payments

Figures shown here come from public SEC filings. Dates beside each section show the available history.

How Septerna, Inc. Makes Money

Follow each dollar of revenue through to what shareholders keep.

From revenue to net income

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Source: Septerna, Inc. — 10-Q filed Aug 10, 2026

Financial Summary

Choose a year or quarter, compare it with the same period a year earlier, and open any row for its full filing history.

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SEC filings supply these figures; updates after the dates shown are not included. This page includes 3 annual periods. The latest annual period ends Dec 31, 2025. The latest insider filing shown is dated Jun 30, 2026.

Ownership

Who holds the shares, as reported in SEC ownership filings.

Unusually large insider trades

Each trade is compared with the other insider trades of the same kind in the same security among Septerna, Inc.'s recent filings on file. Size alone is context, not a prediction or evidence of improper trading.

  • 2026-05-26 · Shaikhly Samira: Larger than 14 of the 15 other insider sales of Common Stock on file. SEC filing
  • 2026-03-02 · Shaikhly Samira: Larger than all 15 other insider sales of Common Stock on file. SEC filing
  • 2025-02-20 · Third Rock Ventures V, L.P.: Larger than 17 of the 18 other insider purchases of Common Stock on file. SEC filing
  • 2024-10-28 · RA Capital Healthcare Fund LP: Larger than all 18 other insider purchases of Common Stock on file. SEC filing

Independent insiders buying near the same time

  • 2025-02-27–2025-03-06: 5 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing )
  • 2025-02-26–2025-03-05: 5 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing )
  • 2025-02-25–2025-03-04: 6 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing , filing )
  • 2025-02-20–2025-02-27: 10 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing , filing , filing , filing , filing , filing )
  • 2025-02-19–2025-02-26: 9 event(s) across 3 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing , filing , filing , filing , filing , filing )
  • 2024-10-28–2024-10-28: 4 event(s) across 2 owner(s) — A cluster counts independent reporting owners that reported purchases within a set time. Co-filers and declared affiliates count once, and duplicate reports of the same event count once. ( filing , filing , filing , filing )

Purchases & sales (open market or private)

SecurityCodePriceFiling
2026-06-29Shaikhly Samira · Chief People OfficerCommon StockS — Open market or private sale−2,17835.18SEC filing
2026-06-22Long Daniel D. · SVP, Drug DiscoveryCommon StockS — Open market or private sale−8,00035.10SEC filing
2026-06-22Long Daniel D. · SVP, Drug DiscoveryCommon StockS — Open market or private sale−7,00035.97SEC filing
2026-06-12Shaikhly Samira · Chief People OfficerCommon StockS — Open market or private sale−6,25035.08SEC filing
2026-06-01Shaikhly Samira · Chief People OfficerCommon StockS — Open market or private sale−1,34628.79SEC filing
2026-06-01Shaikhly Samira · Chief People OfficerCommon StockS — Open market or private sale−1,70027.78SEC filing
2026-06-01Shaikhly Samira · Chief People OfficerCommon StockS — Open market or private sale−2,88929.66SEC filing
2026-05-26Shaikhly Samira · Chief People OfficerCommon StockS — Open market or private sale−11,79830.06SEC filing

Showing 8 of 20 rows

Grants, exercises, tax & gifts

SecurityCodeFiling
2026-06-29Shaikhly Samira · Chief People OfficerStock Option (Right to Buy)M — Exercise or conversion of derivative security−2,178SEC filing
2026-06-29Shaikhly Samira · Chief People OfficerCommon StockM — Exercise or conversion of derivative security+2,178SEC filing
2026-06-26Simson Jake · DirectorStock Option (Right to Buy)A — Grant, award, or other acquisition+15,000SEC filing
2026-06-26Coulie Bernard · DirectorStock Option (Right to Buy)A — Grant, award, or other acquisition+15,000SEC filing
2026-06-26Sharp Shalini · DirectorStock Option (Right to Buy)A — Grant, award, or other acquisition+15,000SEC filing
2026-06-26Tong Jeffrey K · DirectorStock Option (Right to Buy)A — Grant, award, or other acquisition+15,000SEC filing
2026-06-26Bassan Abraham · DirectorStock Option (Right to Buy)A — Grant, award, or other acquisition+15,000SEC filing
2026-06-26Gottesdiener Keith Michael · DirectorStock Option (Right to Buy)A — Grant, award, or other acquisition+11,260SEC filing

Showing 8 of 20 rows

These tables describe filed transactions, not current holdings. Prices are shown as filed; a currency is added only when the filing's data names one. Amended and possible duplicate rows are left out of size comparisons and transaction groups.